Antiviral Services


Antiviral services offered at RetroVirox include a full menu of in vitro antiviral assays against several important human pathogens (RSV, HIV, influenza, DENV, CMV, HBV, LCMV, PIV, and HSV).  Unlike other Contract Research Organizations (CRO), RetroVirox is specialized in offering biological services exclusively in the antiviral field. We work with virtual start-up companies lacking the appropriate facilities to perform antiviral studies, and with large Biotechnology and Pharmaceutical companies seeking CROs with unique expertise in the virology field.


As experts in the antiviral field, we provide a complete menu of antiviral services to evaluate the inhibitory activity of prospective inhibitors. We also offer a number of tailored antiviral assays to address the mechanism of action of novel antivirals. Development of antiviral assays against other viruses is in progress. Evaluation of cytoxicity assays in stable cells or primary cells are available with all antiviral studies.


RetroVirox also offers a multi-viral panel to assess the antiviral efficacy of compounds under development for the treatment of non-viral indications or to evaluate broad-spectrum activities of prospective antivirals (read more). With one of the largest collections of viral strains available (over 200 viral strains of 18 different viral species) RetroVirox can evaluate your molecules for activity against many commercially important human viruses.


RetroVirox does not request ownership nor intellectual property rights over studies or compounds evaluated for other Life Sciences companies.


To request information or quotes call us at (858) 677-9315 or contact us at antivirals@retrovirox.com


To see more information about specific antiviral assays offered against several human viruses click on the following links:



HIV


Influenza and Parainfluenza


Human Respiratory Syncytial Virus (HRSV)


Dengue Virus (DENV)


HSV-1/2


Human Cytomegalovirus (HCMV)


Human Rhinovirus (HRV)


Hepatitis B Virus


Arenaviruses


Multi-virus panel


HTS campaigns with live virus


To request information or quotes call us at (858) 677-9315 or contact us at antivirals@retrovirox.com


Selection of Assays Performed at RetroVirox

  1. Infectivity and replication assays

  2. High Throughput Screening (HTS) against viral targets (45,000 small-molecule library available for pilot studies)

  3. Microneutralization assays

  4. In vitro evaluation of vaccine responses

  5. Plaque reduction assays (PRA)

  6. Virus yield reduction assays

  7. In vitro drug-resistance virus selection

  8. Cross-resistance analyses

  9. Phenotypic characterization of clinical samples (HIV, HRSV, HBV and influenza)

  10. Hemagglutination assays (HA)

  11. Enzymatic assays (viral neuraminidase and viral protease)

  12. Viral replicon assays

  13. Customized virus production (infectious or inactivated)

  14. Combination therapy studies (in vitro)

  15. CPE-based antiviral assays (TCID50)

  16. Mechanism of action studies

  17. Target identification by reverse genetics

  18. Virus stability assessment (virucides and stabilizers)

  19. Comparison of experimental diagnostic tests with commercial assays

  20. In vitro evaluation of microbicides

  21. In vivo models of virus infection

Mechanisms to Access Antiviral Services


RetroVirox offers its services in two modalities to accommodate the need of the smallest and largest companies:

 

Fee-for-service

This is the most common mechanism used for CROs. To request a quote email to antivirals@retrovirox.com or call us at (858) 677-9315.

 

Grant Collaborations

This type of service is not provided by standard CROs. In this mechanism, RetroVirox works as a  “collaborative research organization” rather than a contract research organization. RetroVirox establishes collaborations with companies seeking funds from federal agencies and works with these companies to help them secure financing and meet their R&D antiviral needs.


RetroVirox offers these collaborative opportunities to small start-up companies and mid-size Biotechs with promising therapeutic projects. Our staff will provide FREE guidance in all aspects of the grant application, including the identification of appropriate sources of financing, contacting NIH officers, designing research and business strategies for the proposal, preparing budgets and helping throughout the entire submission process. RetroVirox and its staff have a great deal of expertise in securing awards from multiple sources, including the National Institutes of Health (NIH). Our staff has prepared SBIR (R43, R44), STTR (R41-R42), RO1s, R21s and other NIH grant applications.

 

To inquire about collaborative opportunities to apply for federal grants please email to antivirals@retrovirox.com or call us at (858) 677-9315.